Adrenal Androgens

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Increased Adrenal Androgens in Overweight Peripubertal Girls

Context Peripubertal hyperandrogenemia-a precursor to polycystic ovary syndrome-is prominent in girls with obesity. Objective We examined sources of overnight testosterone (T) and progesterone (P4) and potential sources of obesity-associated hyperandrogenemia during puberty. Design Cross-sectional. Setting Research unit. Participants/Interventions Fifty girls ages 7 to 18 years-both nor...

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The agonistic adrenal: melatonin elicits female aggression via regulation of adrenal androgens.

Classic findings have demonstrated an important role for sex steroids as regulators of aggression, but this relationship is lacking within some environmental contexts. In mammals and birds, the adrenal androgen dehydroepiandrosterone (DHEA), a non-gonadal precursor of biologically active steroids, has been linked to aggression. Although females, like males, use aggression when competing for lim...

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Intra-adrenal factors are not involved in the differential control of cortisol and adrenal androgens in human adrenals.

The differential control of adrenal androgens and cortisol may be due to intra-adrenal factors, which may be age- or sex-related, or due to extra-adrenal factors, such as circulating hormones. The purpose of this study was to identify any intrinsic differences that may exist in steroidogenic production occurring within adrenals obtained from males and females, and any maturational differences t...

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Influences of gonadal and adrenal androgens on the side glands of Suncus murinus.

In order to know the contribution of adrenal and gonadal androgens to the development of the side gland of Suncus murinus, we studied the effects of gonadectomy and adrenalectomy on gland thickness and the plasma levels of testosterone, androstenedione (delta 4-dione) and dehydroepiandrosterone (DHA). In males, castration decreased gland thickness to 71% of the control. The plasma levels of del...

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Bone mineral density in Addison's disease: evidence for an effect of adrenal androgens on bone mass.

It is unknown whether replacement doses of cortisone acetate and the absence of the small amounts of androgens secreted by the adrenal cortex may cause osteoporosis. This was studied in 35 patients (12 men and 23 women) suffering from primary adrenocortical failure and taking cortisone acetate 25-37.5 mg and fludrocortisone 50-100 micrograms daily. Bone mineral density was measured by single ph...

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ژورنال

عنوان ژورنال: Folia Endocrinologica Japonica

سال: 1968

ISSN: 0029-0661

DOI: 10.1507/endocrine1927.44.8_858